Abstract #4347
Deep grey matter iron deposition and brain atrophy in early multiple sclerosis: a longitudinal study
Matthew P Quinn 1,2 , Joseph S Gati 1 , L Martyn Klassen 1 , Marcelo Kremenchutzky 3 , and Ravi S Menon 1,2
1
Centre for Functional and Metabolic Mapping,
Robarts Research Institute, Western University, London,
Ontario, Canada,
2
Department
of Medical Biophysics, Schulich School of Medicine &
Dentistry, Western University, London, Ontario, Canada,
3
Department
of Clinical Neurological Sciences, Schulich School of
Medicine & Dentistry, Western University, London,
Ontario, Canada
A cohort of patients with clinically isolated syndromes
suggestive of early MS and a cohort of age- and
sex-matched healthy controls were followed for 12 to 20
months with imaging every 4 months. Rates of iron
accumulation (R2*) in grey matter nuclei as well as
rates of brain volume loss were compared between groups.
Patients had increased iron accumulation in putamen and
thalamus, as well as significantly increased brain
volume loss. Thalamic iron measurements were
significantly associated with brain volume percentage
change after correction for age and time on-study. These
results suggest iron deposition and atrophy occur in
early MS.
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