Abstract #4348
DTI and Visually Evoked Potential Changes in Mice with Optic Neuritis
Christopher Nishioka 1 , Jennifer Mei 2 , Hsiao-Fang Liang 3 , Wei-Xing Shi 4 , and Shu-Wei Sun 5,6
1
Neuroscience, UC Riverside, Riverside,
California, United States,
2
Basic
Science, Loma Linda University, Loma Linda, United
States,
3
Basic
Science, Loma Linda University, Loma Linda, CALIFORNIA,
United States,
4
Pharmaceutical
Science, Loma Linda University, California, United
States,
5
Basic
Science and Radiation Medicine, Loma Linda University,
California, United States,
6
Neuroscience
and Bioengineering, UC Riverside, California, United
States
Optic neuritis is usually the first symptom of multiple
sclerosis (MS). This condition and its underlying
pathology can be detected in vivo using diffusion tensor
imaging (DTI) or visually evoked potentials (VEPs).
While these two techniques are both sensitive, they
measure very different phenomena. DTI measures
structural disruption of axons and myelin, while VEPs
measure neural conductivity. The sensitivity of both
techniques to early MS pathology and their relationship
to each other remains unclear. This study addresses
these questions and examines DTI and VEP changes in a
model of optic neuritis across a time-course.
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