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Abstract #4355

Comparison of 3T Arterial Spin Labelling and Dynamic Contrast Enhanced MRI in Multiple sclerosis

Afaf S Elsarraj 1 , Paul S Morgan 2 , Cris S Constantinescu 3 , Dorothee P Auer 1 , and Robert A Dineen 1

1 Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 2 Medical Physics, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, 3 Clinical Neurology Group, Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom

Haemodynamic changes have been reported in multiple sclerosis (MS), using MRI techniques. However, the extent to which the perfusion alterations detected are comparable between these techniques is not well understood. In this study we used arterial spin labelling (ASL) and dynamic contrast enhance-MRI (DCE-MRI) to test whether these two techniques are comparable, by comparing cerebral blood flow (CBF) values from basal ganglia in a cohort of MS patients and matched healthy controls. Our findings suggest that DCE-MRI is more sensitive than ASL in measuring perfusion in multiple sclerosis.

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