Abstract #4358
Mapping of the optic nerve in multiple sclerosis patients with and without optic neuritis
Robert L Harrigan 1 , Katrina M Nelson 1 , Lindsey M Dethrage 2 , Robert L Galloway 3 , Bennett A Landman 1,2 , Louise A Mawn 4 , and Seth A Smith 2,5
1
Electrical Engineering, Vanderbilt
University, Nashville, TN, United States,
2
Institute
for Imaging Science, Vanderbilt University, Nashville,
TN, United States,
3
Biomedical Engineering,
Vanderbilt University, Nashville, TN, United States,
4
Ophthalmology
and Neurological Surgery, Vanderbilt University,
Nashville, TN, United States,
5
Radiology
and Radiological Sciences, Vanderbilt University,
Nashville, TN, United States
Patients presenting with optic neuritis (ON), a sudden
inflammation of the optic nerve which impairs vision,
have an increased likelihood of developing MS. We
investigate a recently developed fully-automatic method
for delineation of the optic nerve and surrounding CSF.
Scans were acquired for a population of 26
relapsing-remitting MS patients and 32 healthy controls
with a high contrast T2-weighted VISTA on a 3T Philips
Achieva. Results show significantly decreased optic
nerve radii posterior to the globe in MS patients with
ON (14 of 26). MS patients (12 of 26) without ON show no
significant deviation compared to the control
population.
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