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Abstract #4359

Cortical abnormalities in multiple sclerosis by 7T MRI: Novel imaging insights and update

Yulin Ge 1 , Ilya Kister 2 , Sanjeev Chawla 1 , Tim Sinnecker 3 , Jean-Christophe Brisset 1 , Joseph Herbert 2 , Friedemann Paul 3 , and Jens Wuerfel 3

1 Radiology, NYU Langone Medical Center, New York City, NY, United States, 2 Neurology, NYU Langone Medical Center, New York, United States, 3 Universittsmedizin Gttingen, Berlin, Germany

In vivo evaluation of cortical pathology is still currently challenging. Using ultra-high field 7T MRI, this study showed different types of cortical lesions that are not visible on conventional field-strength MRI, and updated lesion signal, morphology, and the extent of cortical involvement. In particular, higher prevalence of hypointense cortical lesions found in this study may have critical clinical value regarding hemorrhagic susceptibility or unfavorable drug effects in MS patients.

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