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Abstract #4360

Computerised Cognitive Rehabilitation in Multiple Sclerosis May Result in Improved Working Memory

Jamie Campbell 1 , Dawn Langdon 2 , Waqar Rashid 3 , and Mara Cercignani 1

1 Clinical Imaging Sciences Centre, Brighton & Sussex Medical School, University of Sussex, Brighton, East Sussex, United Kingdom, 2 Neuropsychology, University of London, London, United Kingdom, 3 Neurology, Brighton & Sussex University Hospitals NHS Trust, Brighton, East Sussex, United Kingdom

Multiple sclerosis (MS) is a common inflammatory condition affecting the CNS. Between 40-60% of individuals with MS have evidence of cognitive dysfunction. We investigate if a period of computerised, home-based cognitive rehabilitation is effective in improving cognitive performance. Patients with MS and evidence of cognitive impairment were randomly assigned to receive 45-minute, thrice weekly sessions of home-based computerised cognitive training for six weeks or a placebo condition. We present data on the first 17 patients recruited. fMRI was performed during a N-back test. Improvements in n-back performance were observed following training with decreased frontal lobe activations in the treatment group.

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