Abstract #4360
Computerised Cognitive Rehabilitation in Multiple Sclerosis May Result in Improved Working Memory
Jamie Campbell 1 , Dawn Langdon 2 , Waqar Rashid 3 , and Mara Cercignani 1
1
Clinical Imaging Sciences Centre, Brighton &
Sussex Medical School, University of Sussex, Brighton,
East Sussex, United Kingdom,
2
Neuropsychology,
University of London, London, United Kingdom,
3
Neurology,
Brighton & Sussex University Hospitals NHS Trust,
Brighton, East Sussex, United Kingdom
Multiple sclerosis (MS) is a common inflammatory
condition affecting the CNS. Between 40-60% of
individuals with MS have evidence of cognitive
dysfunction. We investigate if a period of computerised,
home-based cognitive rehabilitation is effective in
improving cognitive performance. Patients with MS and
evidence of cognitive impairment were randomly assigned
to receive 45-minute, thrice weekly sessions of
home-based computerised cognitive training for six weeks
or a placebo condition. We present data on the first 17
patients recruited. fMRI was performed during a N-back
test. Improvements in n-back performance were observed
following training with decreased frontal lobe
activations in the treatment group.
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