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Abstract #4362

Age related metabolic consequences of reduced myelin basic protein MRS and MRI of heterozygous Shiverer mice

Juergen Baudewig 1 , Giulia Poggi 2 , Hannelore Ehrenreich 2 , and Susann Boretius 1

1 Section Biomedical Imaging, Dept. of Radiology and Neuroradiology, Christian-Albrechts-University Kiel, Kiel, Germany, 2 Max Planck Institute of Experimental Medicine, Goettingen, Germany

Heterozygous Shiverer mice with mild myelin alteration reductions serve as a model for age-related mental disorders. In this study we demonstrate that these mild changes (1) can be detected by magnetization transfer techniques, (2) have metabolic consequences and (3) changes progress with age. The subtle myelin alterations were best detectable by MT saturation. DTI failed to differentiate affected mice probably due to the nature of myelin alterations. MRS revealed changes in total creatine and taurine and may indicate altered energy metabolism. These findings probably contribute to an better understanding of the role of myelin proteins in development of mental disease.

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