Abstract #4362
Age related metabolic consequences of reduced myelin basic protein MRS and MRI of heterozygous Shiverer mice
Juergen Baudewig 1 , Giulia Poggi 2 , Hannelore Ehrenreich 2 , and Susann Boretius 1
1
Section Biomedical Imaging, Dept. of
Radiology and Neuroradiology,
Christian-Albrechts-University Kiel, Kiel, Germany,
2
Max
Planck Institute of Experimental Medicine, Goettingen,
Germany
Heterozygous Shiverer mice with mild myelin alteration
reductions serve as a model for age-related mental
disorders. In this study we demonstrate that these mild
changes (1) can be detected by magnetization transfer
techniques, (2) have metabolic consequences and (3)
changes progress with age. The subtle myelin alterations
were best detectable by MT saturation. DTI failed to
differentiate affected mice probably due to the nature
of myelin alterations. MRS revealed changes in total
creatine and taurine and may indicate altered energy
metabolism. These findings probably contribute to an
better understanding of the role of myelin proteins in
development of mental disease.
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