Abstract #4363
High-Field Characterization of Spinal Cord Damage in Multiple Sclerosis
Bailey Lyttle 1 , Adrienne Dula 2,3 , Benjamin Conrad 2 , Richard Dortch 2,3 , Megan Barry 4 , Subramaniam Sriram 4 , Shilpa Reddy 4 , Seth Smith 2,3 , and Siddharama Pawate 4
1
Neuroscience, Vanderbilt University,
Nashville, Tennessee, United States,
2
Vanderbilt
University Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States,
3
Radiology
and Radiological Sciences, Vanderbilt University,
Nashville, TN, United States,
4
Neurology,
Vanderbilt University, Nashville, TN, United States
Nearly all patients of multiple sclerosis experience
deficits in movement initiation and somatosensory
stimulation, indicating the progression of lesions and
atrophy within the spinal cord. However, clinical (1.5T)
and low-field (3T) MRI fail to reflect the level of
spinal cord damage necessary to produce such extensive
physical impairment, creating a clinical-radiological
paradox. The application of high-field (7T) MRI and
semi-automatic segmentation correlates clinical
performance not only with spinal cord atrophy but also
with lesion load, suggesting that the
clinical-radiological paradox can be resolved by
increasing the field strength at which peripheral
effects of multiple sclerosis are identified.
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