Relationship of Sodium concentration and T2 relaxation in Multiple Sclerosis
Patricia Alves Da Mota 1 , Marios C Yiannakas 1 , Ferran Prados 1,2 , Manuel Jorge Cardoso 1 , David Paling 3 , Frank Riemer 1 , Daniel Tozer 4 , Sbastien Ourselin 1 , David H Miller 1 , Xavier Golay 5 , Claudia AM Wheeler-Kingshott 1 , and Bhavana S Solanky 1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, UCL Institute
of Neurology, London, England, United Kingdom,
of Medical Physics and Bioengineering Wolfson House,
Translational Imaging Group CMIC, London, England,
of Clinical Neurosciences, University of Sheffield,
Sheffield, England, United Kingdom,
of Clinical Neurosciences, University of Cambridge,
Cambridge, England, United Kingdom,
Research Unit, Department of Brain Repair and
Rehabilitation, UCL Institute of Neurology, London,
England, United Kingdom
In this study we look at the relationship between total
sodium concentration (TSC) and T2 in multiple sclerosis,
both of which are sensitive to demyelination.
T2 increases are seen as the myelin water fraction
reduces due to demyelination. A TSC increase is also
expected as a result of demyelination, which causes an
over-expression of sodium channels along the axon.
However, increased TSC also occurs if extracellular
space increases due to cell swelling or degradation.
Here we look at the interaction between TSC and T2 in
NAWM, NAGM, CSF, T1 and T2 lesions, in relapsing
remitting and secondary progressive MS.
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