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Abstract #4371

Improve Myelin Imaging Biomarkers Specificity by Modeling Extra-cellular Tissue Water

Yong Wang 1,2 , Peng Sun 1 , Qing Wang 1 , Kathryn Trinkaus 3 , Robert T. Naismith 4 , Robert E. Schmidt 4 , Anne H. Cross 2,4 , and Sheng-Kwei Song 1,5

1 Radiology, Washington University in St. Louis, Saint Louis, MO, United States, 2 Hope Center for neurological Disorders, Washington University in St. Louis, Saint Louis, MO, United States, 3 Biostatistics, Washington University in St. Louis, Saint Louis, MO, United States, 4 Neurology, Washington University in St. Louis, Saint Louis, MO, United States, 5 Hope Center for neurological Disorders, Washington University in St. Louis, Saint Louis, m, United States

Diffusion tenor imaging (DTI) radial diffusivity (RD) and magnetization transfer ratio (MTR) are known sensitive to myelin integrity. However, the specificity of DTI and MTR are suboptimal. In this study, both histological myelin quantification and diffusion MRI were conducted on MS spinal cord specimens to assess the effect of extra-cellular tissue water on the specificity of DTI RD. Preliminary findings suggested that extra-cellular tissue water confounded myelin imaging specificity of DTI RD. Findings were also extended to diffusion MRI and MTR of living patients. By differentiating extra-cellular tissue water, myelin imaging specificity can be significantly improved by diffusion basis spectrum imaging (DBSI).

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