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Abstract #4372

Tracking The Individual Lesion Myelination Status In Multiple Sclerosis

Hagen H Kitzler 1 , Caroline Koehler 1 , Hannes Wahl 1 , Tjalf Ziemssen 2 , and Sean C Deoni 3

1 Neuroradiology, Technische Universitaet Dresden, Dresden, SN, Germany, 2 Neurology, Technische Universitaet Dresden, Dresden, SN, Germany, 3 Engineering, Brown University, Providence, RI, United States

In Multiple Sclerosis, an ongoing debate exists on whether the disease is associated with remarkable differences of underlying pathology and variable subsequent degree of myelin loss within focal demyelinating white matter lesions in early disease states. A rapid, reliable whole-brain myelin imaging analysis method would allow the direct testing of this hypothesis. In fact, the in vivo observation of lesional myelination changes would provide a direct tool to detect response to new individualized therapeutic approaches enhancing the intrinsic repair termed remyelination. We present a method to retrieve the individual myelination status of demyelinating lesions and their change over time from mcDESPOT data.

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