Abstract #4373
Venous Oxygenation Mapping in Multiple Sclerosis: A Longitudinal Study
Sanjeev Chawla 1 , Olga Marshall 1 , Jean Christophe Brisset 1 , Hanzhang Lu 2 , Ilya Kister 3 , and Yulin Ge 1
1
Radiology, New York University Langone
Medical Center, New York, NY, United States,
2
Advanced
Imaging Research Center, University of Texas
Southwestern Medical Center, Dallas, Texas, United
States,
3
Neurology,
New York University Langone Medical Center, New York,
NY, United States
To evaluate longitudinal changes in venous oxygenation
(Yv) from superior sagittal sinus in multiple sclerosis
(MS), 17 patients underwent
T2-relaxation-under-spin-tagging imaging at an interval
of 2 years. Twenty-one controls were also included.
Significantly elevations in CPMG-T2 (68.2410.64ms vs
59.657.13ms, p=0.01) and Yv (62.16.25% vs 58.24.08%,
p=0.03) were observed from MS patients compared to
healthy controls. Compared to baseline, a significant
increase in CPMG- T2 was observed at follow-up time
point (68.2410.64ms vs. 95.4618.46ms). Similarly, a
significant increase in Yv was observed at follow-up
(62.16.25% vs. 74.826.51%). TRUST may be a useful
technique for assessing longitudinal variations in Yv in
MS.
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