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Abstract #4374

Evaluation of demyelination in a new myelin basic protein mutant mouse using in vivo MRI

Tom Dresselaers 1 , Kristof Govaerts 1 , James Dooley 2,3 , Uwe Himmelreich 1 , Adrian Liston 2,3 , and Kim A. Staats 2,3

1 Dept of Imaging and Pathology, KU Leuven, Leuven, Leuven, Belgium, 2 Autoimmune Genetics Laboratory, VIB, Leuven, Belgium, 3 Dept. of Microbiology and Immunology, KU Leuven, Leuven, Belgium

In this study anatomical imaging and DTI is used to confirm in vivo the expected demyelination in a novel myelin basic protein mutant that spontaneously developed in our colony. Anatomical imaging and T2 relaxometry and DTI readouts reflect typical changes as also seen in other demyelination models such as the Shiverer mice.

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