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Abstract #4375

MR Perfusion of Human Brain Tumors Demonstrates Increased Blood Volume in Active Tumor before Static Contrast Enhancement or Permeability.

Ajay Nemani 1 , Mirko Vukelich 1 , Kristina Wakeman 2 , Tibor Valyi-Nagy 2 , and Keith Thulborn 1

1 Center for MR Research, University of Illinois at Chicago, Chicago, IL, United States, 2 Pathology, University of Illinois at Chicago, Chicago, IL, United States

The spatial distribution of permeability (Ktrans) and blood volume (Vb) as derived from dynamic contrast enhanced (DCE) MRI and the extended Tofts model has been investigated in human brain tumors to establish which parameter is the earlier marker of tumor progression in grade and for defining actively growing tumor margins. Tumors were sampled with profiles extending across the center and margins of the tumors. A histological study of a resected tumor confirms growth of new vessels with normal endothelial cells with increased Vb prior to increased Ktrans.

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