Meeting Banner
Abstract #4376

Survival prediction of patients with glioblastoma based on combination analysis of mammalian target of rapamycin (mTOR) - epidermal growth factor receptor (EGFR) pathway and dynamic susceptibility contrast (DSC)-MR perfusion imaging

Xiang Liu 1 , Wei Tian 2 , Rajiv Mangla 2 , Mahlon Johnson 2 , and Sven Ekholm 2

1 Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, United States, 2 University of Rochester Medical Center, NY, United States

Gliobasltoma, is the most common primary malignant and fatal brain tumor. The mTOR-EGFR pathway is important for treatment response and overall survival (OS). Our translational research found that the molecular signature of mTOR correlated with maximal rCBV ratio of peri-enhancing tumor area (rCBVperi-tumor), the patients with high rCBVperi-tumor had shorter OS, and combination of rCBVperi-tumor and mTOR could improve prediction of survival time in patients with glioblastoma.

This abstract and the presentation materials are available to members only; a login is required.

Join Here