Survival prediction of patients with glioblastoma based on combination analysis of mammalian target of rapamycin (mTOR) - epidermal growth factor receptor (EGFR) pathway and dynamic susceptibility contrast (DSC)-MR perfusion imaging
Xiang Liu 1 , Wei Tian 2 , Rajiv Mangla 2 , Mahlon Johnson 2 , and Sven Ekholm 2
Department of Imaging Sciences, University
of Rochester Medical Center, Rochester, NY, United
of Rochester Medical Center, NY, United States
Gliobasltoma, is the most common primary malignant and
fatal brain tumor. The mTOR-EGFR pathway is important
for treatment response and overall survival (OS). Our
translational research found that the molecular
signature of mTOR correlated with maximal rCBV ratio of
peri-enhancing tumor area (rCBVperi-tumor), the patients
with high rCBVperi-tumor had shorter OS, and combination
of rCBVperi-tumor and mTOR could improve prediction of
survival time in patients with glioblastoma.
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