Abstract #4390
Relationship of Subventricular Zone with Tumor Blood Volume, Tumor Genomics and Patient Survival in Patients with Glioblastoma : A TCGA Glioma Phenotype Research Group Project
Brent Griffith 1 , Laila Poisson 2 , Lev Bangiyev 3 , Jason Huse 4 , and Rajan Jain 5
1
Radiology, Henry Ford Hospital, Detroit, MI,
United States,
2
Henry
Ford Hospital, MI, United States,
3
Radiology,
Stony Brook University School of Medicine, NY, United
States,
4
Pathology,
Memorial Sloan-Kettering Cancer Center, NY, United
States,
5
Radiology,
NYU School of Medicine, New York, NY, United States
SVZ involvement in GBM patients may offer a unique
location based imaging biomarker in efforts to
individualize therapy and prognosis. Our work has shown
that these tumors also have increased rCBV in NEL
component of the tumor and worse survival as compared to
cortex-originating GBMs. Poor survival and a worse
vascular imaging phenotype probably reflects a more
aggressive tumor, which could be attributed to the
underlying differences in genomic/molecular make up and
therefore, could point to a neural stem cell origin for
these very heterogeneous and highly malignant tumors.
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