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Abstract #4390

Relationship of Subventricular Zone with Tumor Blood Volume, Tumor Genomics and Patient Survival in Patients with Glioblastoma : A TCGA Glioma Phenotype Research Group Project

Brent Griffith 1 , Laila Poisson 2 , Lev Bangiyev 3 , Jason Huse 4 , and Rajan Jain 5

1 Radiology, Henry Ford Hospital, Detroit, MI, United States, 2 Henry Ford Hospital, MI, United States, 3 Radiology, Stony Brook University School of Medicine, NY, United States, 4 Pathology, Memorial Sloan-Kettering Cancer Center, NY, United States, 5 Radiology, NYU School of Medicine, New York, NY, United States

SVZ involvement in GBM patients may offer a unique location based imaging biomarker in efforts to individualize therapy and prognosis. Our work has shown that these tumors also have increased rCBV in NEL component of the tumor and worse survival as compared to cortex-originating GBMs. Poor survival and a worse vascular imaging phenotype probably reflects a more aggressive tumor, which could be attributed to the underlying differences in genomic/molecular make up and therefore, could point to a neural stem cell origin for these very heterogeneous and highly malignant tumors.

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