Multiparametric MRI Towards a Predictive Model to Differentiate Solitary Brain Metastasis from Glioblastoma Multiforme

Solitary brain metastasis and glioblastoma multiforme (can appear similar on conventional MRI and therefore reliable imaging differentiation between MET and GBM is important for medical staging, surgical planning, and therapeutic decision making. In this study we propose and show the advantage of multiparametric MR biomarkers including fractional anisotropy and mean diffusivity derived from DTI, relative cerebral blood volume derived from DSC perfusion and microvascular permeability (Ktrans) derived from dynamic contrast enhanced perfusion towards a predictive model for differentiation of solitary metastasis from GBM.

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