Abstract #4395
Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance
Daniel Coman 1 , Garth Strohbehn 2 , Liang Han 3 , Ragy R. T. Ragheb 2 , Tarek M. Fahmy 2 , Anita J. Huttner 4 , Fahmeed Hyder 1,2 , Joseph M. Piepmeier 3 , Mark Saltzman 2 , and Jiangbing Zhou 2,3
1
Diagnostic Radiology, Yale University, New
Haven, Connecticut, United States,
2
Biomedical
Engineering, Yale University, New Haven, Connecticut,
United States,
3
Neurosurgery,
Yale University, New Haven, Connecticut, United States,
4
Pathology,
Yale University, New Haven, Connecticut, United States
Glioblastoma is the most common malignant tumor of the
CNS. An ideal therapy for glioblastoma must be highly
penetrative and must carry an effective drug payload. To
address drug delivery challenges, we have developed
brain-penetrating nanoparticles comprised of the
FDA-approved copolymer PLGA. We demonstrated that the
NPs are excellent T
2
contrast
agents which allow detection at low concentration by MRI
after CED to the brain and that a single administration
provides controlled release of cargo agents over long
time periods. Therefore, this novel drug delivery
platform can have an immediate impact on monitoring of
treatment in patients with glioblastoma.
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