Meeting Banner
Abstract #4396

Intracellular Sodium (23Na) MRI for Assessment of Response to Cancer Therapies on Brain Tumor Patients

Yongxian Qian 1 , Charles M. Laymon 2 , Matthew J. Oborski 3 , Jan Drappatz 4 , Frank S. Lieberman 4 , and James M. Mountz 2

1 Qian's Lab for MRI, General Labs Cloud LLC, Pittsburgh, PA, United States, 2 Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 3 Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, 4 Neurology and Medicine, University of Pittsburgh, Pittsburgh, PA, United States

This work demonstrates the potential of intracellular sodium concentration as an endogenous imaging biomarker for noninvasive assessment of early response of brain tumors to therapies with radiation and chemotherapy in clinical setting. Eight patients with glioblastoma multiforme (GBM) were studied with intracellular sodium MRI on a clinical 3T scanner at three time points: baseline, 1- and 2-month follow-ups. Quantified total sodium concentration and bound (mostly intracellular) sodium concentration were used to reflect the growth or death of cancer cells in response to therapies.

This abstract and the presentation materials are available to members only; a login is required.

Join Here