Abstract #4396
Intracellular Sodium (23Na) MRI for Assessment of Response to Cancer Therapies on Brain Tumor Patients
Yongxian Qian 1 , Charles M. Laymon 2 , Matthew J. Oborski 3 , Jan Drappatz 4 , Frank S. Lieberman 4 , and James M. Mountz 2
1
Qian's Lab for MRI, General Labs Cloud LLC,
Pittsburgh, PA, United States,
2
Radiology,
University of Pittsburgh, Pittsburgh, PA, United States,
3
Bioengineering,
University of Pittsburgh, Pittsburgh, PA, United States,
4
Neurology
and Medicine, University of Pittsburgh, Pittsburgh, PA,
United States
This work demonstrates the potential of intracellular
sodium concentration as an endogenous imaging biomarker
for noninvasive assessment of early response of brain
tumors to therapies with radiation and chemotherapy in
clinical setting. Eight patients with glioblastoma
multiforme (GBM) were studied with intracellular sodium
MRI on a clinical 3T scanner at three time points:
baseline, 1- and 2-month follow-ups. Quantified total
sodium concentration and bound (mostly intracellular)
sodium concentration were used to reflect the growth or
death of cancer cells in response to therapies.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
