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Abstract #4397

Electrical Conductivity Characteristics of Meningiomas: Noninvasive Assessment using Electric Properties Tomography

Khin Khin Tha 1 , Ulrich Katscher 2 , Christian Stehning 2 , Shigeru Yamaguchi 3 , Shunsuke Terasaka 3 , Hiroyuki Sugimori 3 , Toru Yamamoto 4 , Noriyuki Fujima 3 , Kohsuke Kudo 3 , Yuriko Suzuki 5 , Marc van Cauteren 5 , and Hiroki Shirato 1

1 Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan, 2 Philips Research Laboratories, Hamburg, Germany, 3 Hokkaido University Hospital, Japan, 4 Hokkaido University Graduate School of Health Sciences, Japan, 5 Philips Electronics, Japan

To characterize electrical conductivity characteristics of meningiomas noninvasively, MRI including electric properties tomography (EPT) was conducted in patients with meningioma, low grade glioma, and lymphoma. The conductivity characteristics of meningiomas, conductivity variations between the tumor and adjacent gray matter, among tumor grades and subtypes, betweeen meningiomas and other tumors, were evaluated. Correlation between the conductivity and Ki67 or mean diffusivity (MD) values of meningiomas was also tested. The major histogram metrics of meningioma varied significantly from gray matter. Meningiomas had lower minimum and broader width of conductivity histograms than lymphomas. Its maximum conductivity correlated inversely with the minimum MD.

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