Abstract #4398
Noninvasive Characterization and Staging of Glioma with MR Elastography - A Pilot Study
Kay Pepin 1 , Arvin Arani 2 , Nikoo Fattahi 2 , Armando Manduca 3 , Richard L Ehman 2 , John Huston III 2 , and Kiaran McGee 2
1
Graduate School, Mayo Clinic, Rochester,
Minnesota, United States,
2
Radiology,
Mayo Clinic, Minnesota, United States,
3
Physiology
and Biomedical Engineering, Mayo Clinic, Minnesota,
United States
Currently, no noninvasive technique exists for the
accurate classification of tumor grade in glioma. Tumor
mechanical properties quantified using magnetic
resonance elastography may be used for the noninvasive
staging of glioma. In this study, we have shown the
feasibility of using MRE to quantify shear stiffness in
glioma and demonstrated an inverse relationship between
stiffness and tumor grade.The results of this study show
the potential of using shear stiffness as a biomarker
for tumor grade in glioma.
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