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Abstract #4398

Noninvasive Characterization and Staging of Glioma with MR Elastography - A Pilot Study

Kay Pepin 1 , Arvin Arani 2 , Nikoo Fattahi 2 , Armando Manduca 3 , Richard L Ehman 2 , John Huston III 2 , and Kiaran McGee 2

1 Graduate School, Mayo Clinic, Rochester, Minnesota, United States, 2 Radiology, Mayo Clinic, Minnesota, United States, 3 Physiology and Biomedical Engineering, Mayo Clinic, Minnesota, United States

Currently, no noninvasive technique exists for the accurate classification of tumor grade in glioma. Tumor mechanical properties quantified using magnetic resonance elastography may be used for the noninvasive staging of glioma. In this study, we have shown the feasibility of using MRE to quantify shear stiffness in glioma and demonstrated an inverse relationship between stiffness and tumor grade.The results of this study show the potential of using shear stiffness as a biomarker for tumor grade in glioma.

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