Abstract #4401
MRI Monitoring of Stem Cells Transplantation in Traumatic Brain Injury Mice and its Therapeutic Potential
Sushanta Kumar Mishra 1 , Subash Khushu 1 , and Gangenahalli U Gurudutta 2
1
NMR Research Centre, Institute of Nuclear
Medicine and Allied Sciences, DRDO, Delhi, Delhi, India,
2
Stem
Cells Research Group, Institute of Nuclear Medicine and
Allied Sciences, DRDO, Delhi, Delhi, India
Application of stem cells based therapeutic approaches
in experimental models likely becomes a realistic
alternative to conventional treatments. The mMSCs were
labelled with D-Fe3O4 nanoparticles and fluorescent
PKH26 dye. Transplantation of labelled stem cells in
traumatic brain injury mice were monitored by 7T animal
MRI and confocal microscopy. T2/T2* values were
decreased significantly at the injury site on day-3,
which indicated homing of the stem cells to the site of
injury. Stem cells transplantation enhanced the
therapeutic activity in TBI mice in terms of functional
outcome like cognition, depression and locomotion.
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