Abstract #4402
Static and Dynamic Functional Connectivity Impairments in Concussed Soldiers with and without PTSD
D Rangaprakash 1 , Gopikrishna Deshpande 1,2 , Thomas A Daniel 2 , Adam Goodman 2 , Jeffrey S Katz 1,2 , Nouha Salibi 1,3 , Thomas S Denney Jr 1,2 , and MAJ Michael N Dretsch 4,5
1
AU MRI Research Center, Department of
Electrical and Computer Engineering, Auburn University,
Auburn, AL, United States,
2
Department
of Psychology, Auburn University, Auburn, AL, United
States,
3
MR
R&D, Siemens Healthcare, Malvern, PA, United States,
4
National
Intrepid Center of Excellence, Walter Reed National
Military Medical Center, Bethesda, MD, United States,
5
U.S.
Army Aeromedical Research Laboratory, Fort Rucker, AL,
United States
We performed connectivity analysis of resting-state fMRI
data obtained from Soldiers with PTSD and co-occurring
post-concussion syndrome (PCS), along with matched
military controls. We used static and dynamic functional
connectivity measures. We tested the hypothesis that
PTSD and PCS are associated with increased connectivity
strength, but lower connectivity variance (calculated
over time) compared to controls. The connectivity
between striatum and hippocampus fit the above
hypothesis, with additional burden in the comorbid
group. This suggests that PTSD and PCS are associated
with a hyper-connectivity state from which it is
difficult to disengage, often observed with habit
formation.
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