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Abstract #4402

Static and Dynamic Functional Connectivity Impairments in Concussed Soldiers with and without PTSD

D Rangaprakash 1 , Gopikrishna Deshpande 1,2 , Thomas A Daniel 2 , Adam Goodman 2 , Jeffrey S Katz 1,2 , Nouha Salibi 1,3 , Thomas S Denney Jr 1,2 , and MAJ Michael N Dretsch 4,5

1 AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, 2 Department of Psychology, Auburn University, Auburn, AL, United States, 3 MR R&D, Siemens Healthcare, Malvern, PA, United States, 4 National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, United States, 5 U.S. Army Aeromedical Research Laboratory, Fort Rucker, AL, United States

We performed connectivity analysis of resting-state fMRI data obtained from Soldiers with PTSD and co-occurring post-concussion syndrome (PCS), along with matched military controls. We used static and dynamic functional connectivity measures. We tested the hypothesis that PTSD and PCS are associated with increased connectivity strength, but lower connectivity variance (calculated over time) compared to controls. The connectivity between striatum and hippocampus fit the above hypothesis, with additional burden in the comorbid group. This suggests that PTSD and PCS are associated with a hyper-connectivity state from which it is difficult to disengage, often observed with habit formation.

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