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Abstract #4406

Diffusion MRI Connectometry Findings and Symptom Reporting Following Traumatic Brain Injury

Ping-Hong Yeh 1 , Fang-Cheng Yeh 2 , John Ollinger 3 , Elyssa B. Sham 3 , Binquan Wang 1 , David Joy 1 , Justin Senseney 3 , Terrence R. Oakes 3 , and Gerard Riedy 3

1 Henry Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States, 2 Department of Psychology & Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburg, Pennsylvania, United States, 3 National Intrepid Center of Excellence, Bethesda, Maryland, United States

Relating clinical symptoms to brain structural changes is critical in understanding the sequalae following brain injury. Due to the essence of axonal loss in TBI, conventional tractography paradigm, requiring accurate tracks/connectome reconstruction in order to compare the group/individual difference, may miss lesions over the paths failed to reconstruct tracts. Using q space diffeomorphic reconstruction to identify affected pathways, diffusion MRI connectometry finds local difference in diffusion distribution,avoids any inaccuracy in fiber tracking. We applied this approach to relate self-reporting symptoms in military TBI patients to the affected white matter tracts.

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