Abstract #4407
Diffusion-derived MRI Measures of Longitudinal Microstructural Remodeling Induced by Marrow Stromal Cell Therapy after TBI
Lian Li 1 , Michael Chopp 1,2 , Guangliang Ding 1 , Changsheng Qu 3 , Siamak P Nejad-Davarani 1 , Esmaeil Davoodi-Bojd 1 , Qingjiang Li 1 , Asim Mahmood 3 , and Quan Jiang 1,2
1
Neurology, Henry Ford Hospital, Detroit, MI,
United States,
2
Physics,
Oakland University, MI, United States,
3
Neurosurgery,
Henry Ford Hospital, Detroit, MI, United States
The capacity and sensitivity of diffusion-derived
measures, fractional anisotropy (FA) and entropy, to
dynamically detect the therapeutic effect of human bone
marrow stromal cells (hMSCs) on traumatic brain injury
(TBI) were investigated. Compared to delayed cell
engraftment (1-week) after TBI, acute cell intervention
(6-hour) promotes structural reorganization in the
injured brain. While FA and entropy present the similar
capacity to longitudinally detect the microstructural
changes in the tissue region with predominant
orientation of fiber tracts, entropy exhibits the
sensitivity, superior to FA, in probing the structural
alterations in the area with crossing fibers.
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