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Abstract #4407

Diffusion-derived MRI Measures of Longitudinal Microstructural Remodeling Induced by Marrow Stromal Cell Therapy after TBI

Lian Li 1 , Michael Chopp 1,2 , Guangliang Ding 1 , Changsheng Qu 3 , Siamak P Nejad-Davarani 1 , Esmaeil Davoodi-Bojd 1 , Qingjiang Li 1 , Asim Mahmood 3 , and Quan Jiang 1,2

1 Neurology, Henry Ford Hospital, Detroit, MI, United States, 2 Physics, Oakland University, MI, United States, 3 Neurosurgery, Henry Ford Hospital, Detroit, MI, United States

The capacity and sensitivity of diffusion-derived measures, fractional anisotropy (FA) and entropy, to dynamically detect the therapeutic effect of human bone marrow stromal cells (hMSCs) on traumatic brain injury (TBI) were investigated. Compared to delayed cell engraftment (1-week) after TBI, acute cell intervention (6-hour) promotes structural reorganization in the injured brain. While FA and entropy present the similar capacity to longitudinally detect the microstructural changes in the tissue region with predominant orientation of fiber tracts, entropy exhibits the sensitivity, superior to FA, in probing the structural alterations in the area with crossing fibers.

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