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Abstract #4408

Preliminary Multimodal MR Imaging Evaluation in Blast-induced Traumatic Brain Injury Rat Model

Xiao Wang 1 , Xiao-hong Zhu 1 , Afshin Divani 2 , Yi Zhang 1 , and Wei Chen 1

1 Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota, United States, 2 Department of Neurology, University of Minnesota, Minnesota, United States

Blast-induced traumatic brain injury (bTBI) is of particular relevance to the military battles and urban terrorist attacks and has increasingly gained public attention. Proper preclinical bTBI models and noninvasive neuroimaging tools are crucial for early diagnosis, neuropathology progression monitor and treatment efficacy evaluation. We performed multiple MRI measures in a new bTBI rat model and found a highly synchronized and widely distributed rs-fMRI connectivity across almost the entire brain in some of the bTBI rats. This rs-fMRI characteristic is not sensitive to the presence of macroscopic lesion, baseline cerebral blood flow (CBF) and impaired cerebrovascular reactivity, but is persistent in the same rat for a long period of time. The abnormal connectivity pattern of lacking functional specificity might be related to the diminished brain functional segregation, disrupted neural excitation and/or inhibition and compensatory neuronal processes caused by the injury. The overall results reveal that the rs-fMRI can serve as a sensitive neuroimaging biomarker for noninvasively studying the underlying neuropathology mechanisms of the bTBI using a rat model, which should have a constructive impact for clinical translation in human TBI patients.

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