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Abstract #4409

Symptomatic White Matter and Gray Matter Changes in Mild Traumatic Brain Injury

Ping-Hong Yeh 1 , Jennifer Pacheco 2 , Joseph Hennessey 2 , Alex Kubli 2 , Priya Santhanam 2 , Terrence R. Oakes 2 , Thomas Perkins 3 , Gerard Riedy 2 , William W. Orrison 4 , and Lindell K. Weaver 5,6

1 Henry Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States, 2 National Intrepid Center of Excellence, Bethesda, Maryland, United States, 3 Philips Healthcare, Cleveland, Ohio, United States, 4 Nevada Imaging Centers, Las Vegas, Nevada, United States, 5 Department of Hyperbaric Medicine, Intermountain LDS Hospital and Intermountain Medical Center, Salt Lake City, Utah, United States, 6 School of Medicine, University of Utah, Utah, United States

Simultaneous detection of the gray matter and white matter microstructural lesions is important in understanding the pathophysiologic mechanisms following brain injury. In this study, we applied multivariate analysis to assess gray matter and white matter microstructural changes in mild TBI (mTBI) patients with persistent post-concussive symptoms. Our findings support that multivariate analysis is superior to conventional univariate analysis in detecting aberrant white matter and gray matter changes in mTBI patients with post-concussive syndrome.

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