Abstract #4409
Symptomatic White Matter and Gray Matter Changes in Mild Traumatic Brain Injury
Ping-Hong Yeh 1 , Jennifer Pacheco 2 , Joseph Hennessey 2 , Alex Kubli 2 , Priya Santhanam 2 , Terrence R. Oakes 2 , Thomas Perkins 3 , Gerard Riedy 2 , William W. Orrison 4 , and Lindell K. Weaver 5,6
1
Henry Jackson Foundation for the Advancement
of Military Medicine, Bethesda, Maryland, United States,
2
National
Intrepid Center of Excellence, Bethesda, Maryland,
United States,
3
Philips
Healthcare, Cleveland, Ohio, United States,
4
Nevada
Imaging Centers, Las Vegas, Nevada, United States,
5
Department
of Hyperbaric Medicine, Intermountain LDS Hospital and
Intermountain Medical Center, Salt Lake City, Utah,
United States,
6
School
of Medicine, University of Utah, Utah, United States
Simultaneous detection of the gray matter and white
matter microstructural lesions is important in
understanding the pathophysiologic mechanisms following
brain injury. In this study, we applied multivariate
analysis to assess gray matter and white matter
microstructural changes in mild TBI (mTBI) patients with
persistent post-concussive symptoms. Our findings
support that multivariate analysis is superior to
conventional univariate analysis in detecting aberrant
white matter and gray matter changes in mTBI patients
with post-concussive syndrome.
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