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Abstract #4419

Robust Detection of Axonal Abnormalities in High School Collision-Sport Athletes: Longitudinal Single Subject Analysis

Ikbeom Jang 1 , Il Yong Chun 1 , Larry J. Leverenz 2 , Eric A. Nauman 3,4 , and Thomas M. Talavage 1,4

1 School of Electrical & Computer Engineering, Purdue Universisty, West Lafayatte, Indiana, United States, 2 Department of Health & Kinesiology, Purdue Universisty, Indiana, United States, 3 School of Mechanical Engineering, Purdue Universisty, Indiana, United States, 4 Weldon School of Biomedical Engineering, Purdue Universisty, Indiana, United States

Using diffusion-weighted MR imaging, a single subject-based approach is proposed here to detect athletes exhibiting longitudinal deviations in fractional anisotropy (FA) as observed by paired tract-based spatial statistics (TBSS). High-school aged male football and female soccer athletes were scanned longitudinally three times during the course of a competition season, during which they experienced multiple collisions to the head or whiplash-like acceleration events. Significant increases in FA were observed in the second half of the season, relative to the pre-season measures, for most asymptomatic soccer players.

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