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Abstract #4420

Detecting atrophy in chronic moderate and severe traumatic brain injury using an automated volume-based morphometry toolbox

Yang Wang 1,2 , Benedicte Marechal 3,4 , Dawn Neumann 2 , Alexis Roche 3,4 , John D West 2 , Brenna C McDonald 2 , Michelle A Keiski 2 , Dori J Smith 2 , Andrew J Saykin 2 , and Gunnar Kruger 3,4

1 Medical College of Wisconsin, Milwaukee, WI, United States, 2 Indiana University School of Medicine, Indianapolis, IN, United States, 3 Siemens Healthcare IM BM PI & Department of Radiology CHUV, Lausanne, Switzerland, 4 LTS5, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland

Identification of structural abnormalities in chronic traumatic brain injury (TBI) remains challenging because the brain often appears quite normal on conventional CT and MRI scans. Using an automatic volume-based morphometry toolbox, we have evaluated atrophy in chronic moderate and severe TBI that is associated with severity of cognitive deficit. Our results suggest the usefulness of this toolbox in clinical settings for fast volumetric analysis without complex post-processing steps.

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