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Abstract #4421

DTI parametric lesion load is a better surrogate marker when regional analysis is insensitive to distinguish between control and TBI population.

Ramtilak Gattu 1 , Robert Welch 2 , Brian Oneil 3 , Anamika Chaudhary 1 , Ewart Mark Haacke 1 , and Zhifeng Kou 1

1 Radiology, wayne state university, Detroit, Michigan, United States, 2 Emergency Medicine, wayne state university, Detroit, Michigan, United States, 3 Emergency Medicine, wayne state university, Michigan, United States

A regional and lesion load analysis of different DTI parametric maps has been investigated; we have found that when regional analysis fails to be sensitive enough in distinguishing between the groups, lesion load can serve as surrogate marker that helps in diagnosis of neurocognitive or neurological deficits in the TBI population. A strong positive correlation also have been associated between decreased FA lesion load and increased radial diffusivity, decreased axial diffusivity, increased apparent diffusion coefficient and increased trace lesion load. These different associations might give us better understanding behind the strong driving forces in predicting the FA white matter changes.

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