Abstract #4421
DTI parametric lesion load is a better surrogate marker when regional analysis is insensitive to distinguish between control and TBI population.
Ramtilak Gattu 1 , Robert Welch 2 , Brian Oneil 3 , Anamika Chaudhary 1 , Ewart Mark Haacke 1 , and Zhifeng Kou 1
1
Radiology, wayne state university, Detroit,
Michigan, United States,
2
Emergency
Medicine, wayne state university, Detroit, Michigan,
United States,
3
Emergency Medicine, wayne
state university, Michigan, United States
A regional and lesion load analysis of different DTI
parametric maps has been investigated; we have found
that when regional analysis fails to be sensitive enough
in distinguishing between the groups, lesion load can
serve as surrogate marker that helps in diagnosis of
neurocognitive or neurological deficits in the TBI
population. A strong positive correlation also have been
associated between decreased FA lesion load and
increased radial diffusivity, decreased axial
diffusivity, increased apparent diffusion coefficient
and increased trace lesion load. These different
associations might give us better understanding behind
the strong driving forces in predicting the FA white
matter changes.
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