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Abstract #4425

Development and Implementation of Amide Proton Transfer Chemical Exchange Saturation Transfer in the Spinal Cord at 3T Using Lorentzian Difference Analysis

Samantha By 1,2 , Alex K. Smith 1,2 , Lindsey M. Dethrage 2 , Adrienne N. Dula 2,3 , Siddharma Pawate 4 , and Seth A. Smith 2,3

1 Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2 Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 3 Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 4 Department of Neurology, Vanderbilt University, Nashville, TN, United States

Amide proton transfer (APT) CEST has the potential to probe metabolic composition of spinal cord lesions in diseases such as multiple sclerosis (MS). Due to the inherent challenges of spinal cord imaging, however, there are few reports of APT CEST in the spinal cord, making translation to diseased cohorts difficult. We investigate the application of a pulsed CEST acquisition with a Lorentzian difference analysis in healthy controls and a MS patient with known spinal cord lesions. Initial results demonstrate profound tissue changes marked by increased APT concentrations at the lesion sites in the MS patient relative to healthy controls.

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