Abstract #4425
Development and Implementation of Amide Proton Transfer Chemical Exchange Saturation Transfer in the Spinal Cord at 3T Using Lorentzian Difference Analysis
Samantha By 1,2 , Alex K. Smith 1,2 , Lindsey M. Dethrage 2 , Adrienne N. Dula 2,3 , Siddharma Pawate 4 , and Seth A. Smith 2,3
1
Department of Biomedical Engineering,
Vanderbilt University, Nashville, TN, United States,
2
Vanderbilt
University Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States,
3
Department
of Radiology and Radiological Sciences, Vanderbilt
University, Nashville, TN, United States,
4
Department
of Neurology, Vanderbilt University, Nashville, TN,
United States
Amide proton transfer (APT) CEST has the potential to
probe metabolic composition of spinal cord lesions in
diseases such as multiple sclerosis (MS). Due to the
inherent challenges of spinal cord imaging, however,
there are few reports of APT CEST in the spinal cord,
making translation to diseased cohorts difficult. We
investigate the application of a pulsed CEST acquisition
with a Lorentzian difference analysis in healthy
controls and a MS patient with known spinal cord
lesions. Initial results demonstrate profound tissue
changes marked by increased APT concentrations at the
lesion sites in the MS patient relative to healthy
controls.
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