Abstract #4428
Slice-by-slice regularized registration for spinal cord MRI: SliceReg
J. Cohen-Adad 1,2 , S. Lvy 1 , and B. Avants 3
1
Institute of Biomedical Engineering,
Polytechnique Montreal, Montreal, QC, Canada,
2
Functional
Neuroimaging Unit, CRIUGM, Universit de Montral,
Montreal, QC, Canada,
3
PENN
Image Computing & Science Lab, Dept of Radiology, UPENN,
Philadelphia, PA, United States
Within-subject registration of spinal cord data is a
difficult problem because the articulated nature of the
spine can produce non-rigid deformations. To address
this, researchers have introduced slice-by-slice
registration using only translations within the axial
plane. Although more accurate than volume-based
transformations, this approach lacks robustness because
each slice is treated independently from the others.
Here we introduce a novel method (SliceReg) that
estimates slice-by-slice transformations with polynomial
regularization along the spinal cord axis. SliceReg has
been validated in 25 datasets and shows higher accuracy
than volume-based transformations and benefit from
regularization in comparison with slice-by-slice
techniques.
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