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Abstract #4429

Whole post-mortem spinal cord imaging with diffusion-weighted steady state free precession at 7T

Sean Foxley 1 , Jeroen Mollink 1 , Olaf Ansorge 2 , Connor Scott 2 , Saad Jbabdi 1 , Richard Yates 2 , Gabriele De Luca 2 , and Karla Miller 1

1 FMRIB Centre, University of Oxford, Oxford, OXON, United Kingdom, 2 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OXON, United Kingdom

Post-mortem imaging has begun to attract interest as a method for anatomical investigation that can achieve higher resolution than in-vivo imaging and be directly compared against histological gold standards. In this work we investigate collecting diffusion weighted data of whole post-mortem human spinal cord at 7T using diffusion-weighted SSFP. Tractography and fibre population estimate results demonstrate that methodological and procedural developments produce high fidelity data with coherent primary diffusion direction estimates and significant secondary collateral fibre estimates. Correlation with PLI data demonstrates the potential for validating collateral fibre orientations with MR data.

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