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Abstract #4430

Comparison between histology and MRI markers of white matter damage in contused rat spinal cords treated with transplanted Schwann cells: correlation analysis based on image registration

Andrew C.H. Yung 1 , Peggy Assinck 2 , Di Leo Wu 3 , Jie Liu 2 , Shaalee Dworski 4 , Freda Miller 4 , Wolfram Tetzlaff 2,5 , and Piotr Kozlowski 1,2

1 UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 2 ICORD, Vancouver, BC, Canada, 3 Physics, University of British Columbia, Vancouver, BC, Canada, 4 Hospital for Sick Children, Toronto, ON, Canada, 5 Zoology, University of British Columbia, Vancouver, BC, Canada

Using an image registration approach, we assess the spatial correlation between ex vivo myelin water fraction (MWF) and transverse diffusivity (Dtrans) to histology-derived myelin area fraction (EC+P0 area fraction) in a contusion rat model of spinal cord injury, with and without treatment with SKP-SC cell therapy. Pearson coefficients for EC+P0 area fraction vs. MWF and Dtrans were 0.69 and -0.49, respectively. MWF and EC+P0 area fraction both showed a higher myelin content in the SKP-SC treated group as compared to cords injected with media alone, whereas Dtrans did not detect any statistically significant differences between groups.

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