Abstract #4430
Comparison between histology and MRI markers of white matter damage in contused rat spinal cords treated with transplanted Schwann cells: correlation analysis based on image registration
Andrew C.H. Yung 1 , Peggy Assinck 2 , Di Leo Wu 3 , Jie Liu 2 , Shaalee Dworski 4 , Freda Miller 4 , Wolfram Tetzlaff 2,5 , and Piotr Kozlowski 1,2
1
UBC MRI Research Centre, University of
British Columbia, Vancouver, BC, Canada,
2
ICORD,
Vancouver, BC, Canada,
3
Physics,
University of British Columbia, Vancouver, BC, Canada,
4
Hospital
for Sick Children, Toronto, ON, Canada,
5
Zoology,
University of British Columbia, Vancouver, BC, Canada
Using an image registration approach, we assess the
spatial correlation between ex vivo myelin water
fraction (MWF) and transverse diffusivity (Dtrans) to
histology-derived myelin area fraction (EC+P0 area
fraction) in a contusion rat model of spinal cord
injury, with and without treatment with SKP-SC cell
therapy. Pearson coefficients for EC+P0 area fraction
vs. MWF and Dtrans were 0.69 and -0.49, respectively.
MWF and EC+P0 area fraction both showed a higher myelin
content in the SKP-SC treated group as compared to cords
injected with media alone, whereas Dtrans did not detect
any statistically significant differences between
groups.
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