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Abstract #4442

Investigating functional-structural correlations in the cervical spinal cord in vivo

Moreno Pasin 1 , Marios C Yiannakas 1 , Ahmed T Toosy 2 , and Claudia A M Wheeler-Kingshott 1

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre‚Äč, UCL Institute of Neurology, London, England, United Kingdom, 2 Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, England, United Kingdom

Investigating spinal cord function and white matter microstructure using MRI implies coping with several technical issues. This study uses a protocol matching functional and structural spinal images and investigates correlations between functional and structural parameters obtained in 10 healthy controls undertaking a sensory task delivered on both left and right hand separately. Signal enhancement and lateralization index(LI) are reported. Fractional anisotropy(FA), radial diffusivity(RD), axial diffusivity(AD) and mean diffusivity(MD) were calculated in ROIs drawn on: whole cord, right hemisphere, left hemisphere and posterior column white matter. No correlation was found between LI and the FA, MD, RD and AD values for any ROIs.

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