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Abstract #4443

Comparison between DTI, MWF, and frequency shift mapping in assessing white matter damage of spinal cord

Evan I-Wen Chen 1,2 , Jie Liu 2 , Vanessa Wiggermann 1 , Andrew Yung 1 , Alexander Rauscher 1,3 , and Piotr Kozlowski 1,3

1 MRI Research Center, Vancouver, BC, Canada, 2 International Collaboration On Repair Discoveries, Vancouver, BC, Canada, 3 Radiology, University of British Columbia, Vancouver, BC, Canada

Gold standard histology is used to characterize degeneration pathology in an injury model that generates white matter injury in CNS (spinal cord). We compare DTI, MWF, and frequency shift mapping to evaluate effectiveness, advantages, and disadvantages of each. Frequency shift mapping is sensitive relative to changes to histology, and has advantages of higher spatial resolution, higher SNR, and lower scan times compared to MWF and DTI. Frequency shift mapping can benefit from structural information from DTI to better separate the effects of axonal or myelin damage to improve the accuracy of MRI of spinal cord transection injury.

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