Comparison between DTI, MWF, and frequency shift mapping in assessing white matter damage of spinal cord
Evan I-Wen Chen 1,2 , Jie Liu 2 , Vanessa Wiggermann 1 , Andrew Yung 1 , Alexander Rauscher 1,3 , and Piotr Kozlowski 1,3
MRI Research Center, Vancouver, BC, Canada,
Collaboration On Repair Discoveries, Vancouver, BC,
University of British Columbia, Vancouver, BC, Canada
Gold standard histology is used to characterize
degeneration pathology in an injury model that generates
white matter injury in CNS (spinal cord). We compare
DTI, MWF, and frequency shift mapping to evaluate
effectiveness, advantages, and disadvantages of each.
Frequency shift mapping is sensitive relative to changes
to histology, and has advantages of higher spatial
resolution, higher SNR, and lower scan times compared to
MWF and DTI. Frequency shift mapping can benefit from
structural information from DTI to better separate the
effects of axonal or myelin damage to improve the
accuracy of MRI of spinal cord transection injury.
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