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Abstract #4444

Optimization of Spinal Cord NODDI Protocol with Multi-band EPI for Clinical Use

Masaaki Hori 1,2 , Ryuji Nojiri 2 , Katsutoshi Murata 3 , Yuichi Suzuki 4 , Koji Kamagata 1 , Mariko Yoshida 1 , Kouhei Tsuruta 1,5 , Keiichi Ishigame 2 , and Shigeki Aoki 1

1 Radiology, Juntendo University School of Medicine, Tokyo, Japan, 2 Tokyo Medical Clinic, Tokyo, Japan, 3 Siemens Japan K.K., Tokyo, Japan, 4 Radiology, The University of Tokyo Hospital, Tokyo, Japan, 5 Department of Health Science, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan

We investigate the effect of multi-band reduction factor (MBf) on Neurite orientation dispersion and density imaging (NODDI) metrics and to compare less number of motion probing gradient (MPG) axes 2-shell protocol NODDI metrics with 2-shell 30 MPG protocol in the cervical spinal cord white matter in vivo. Between Mbf 2 and 3 data, there were significant differences in ICVF and IVF. With increasing of number of measurements, improved agreement was observed between 30 MPG data metrics and less number MPG data. Therefore, we recommend that more than 24 MPG axes and MBf of 2 for spinal cord NODDI with multiband-EPI.

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