Feasibility Analysis of the Chemical Exchange and T 1 Measurement Using Progressive Saturation (CUPS) Method for In Vivo Application to Human Myocardium

The creatine kinase (CK) reaction is considered to be important for maintaining ATP supply to demand in the myocardium over the wide operating range of cardiac output. The CUPS method has been previously applied to measurements of chemical exchange rates, such as CK flux, under preclinical experimental conditions. The current work uses Cramr-Rao lower bound analysis and Monte Carlo simulations, targeting in vivo human MRS conditions for studies of the myocardium at clinical field strength, demonstrating the feasibility of this approach for reliable measurement of CK fluxes under a wide range of experimental and physiological conditions.

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