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Abstract #4463

Late Gadolinium Enhancement for Left Ventricular Lead Guidance in Cardiac Resynchronization Therapy: Comparison of 3D Free-breathing IR-FLASH vs 2D Breath-hold Phase-Sensitive IR

Adrian Lam 1 , Ankit Parikh 2 , Michael Lloyd 2 , and John Oshinski 1,3

1 Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States, 2 Department of Medicine, Emory University, Georgia, United States, 3 Department of Radiology and Imaging Science, Emory University, Georgia, United States

Optimal patient response to Cardiac Resynchronization Therapy is associated with left ventricular lead implantation in the latest contracting segment of the myocardium that is not predominantly myocardial scar. However, transvenous implantation through the coronary sinus limits lead implantation locations to regions that can be accessed by the coronary veins. A 3D, contrast-enhanced, free-breathing inversion recovery (IR) FLASH sequence can visualize the coronary veins and can be used for late gadolinium enhanced (LGE) imaging. The purpose of this study was to evaluate the potential of 3D, LGE, free-breathing, IR-prepared FLASH compared to the clinical standard, 2D LGE Phase Sensitive Inversion-Recovery (PSIR).

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