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Abstract #4475

Improvement of Left Ventricular Strain with Reduction of Mean Pulmonary Arterial Pressure in Pulmonary Hypertension: Treatment Effect Independent of Right Ventricular Volumetric Parameters.

Tomoyoshi Kimura 1,2 , Hideki Ota 1 , Koichiro Sugimura 3 , Kazuomi Yamanaka 1 , Tatsuo Nagasaka 1 , Hiroaki Shimokawa 3 , Kei Takase 1 , and Haruo Saito 2

1 Radiology, Tohoku University Hospital, Sendai, Miyagi, Japan, 2 Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan, 3 Cardiology, Tohoku University Hospital, Sendai, Miyagi, Japan

We enrolled 11 patients with chronic thromboembolic pulmonary hypertension and one with idiopathic pulmonary arterial hypertension. Biventricular function and left ventricular (LV) strain analyses were performed before and after treatment. MR-derived parameters of cardiac functions were compared with mean pulmonary arterial pressure (mPAP). All patients demonstrated normal LV ejection fraction at baseline. Right ventricular (RV) end-systolic and end-diastolic volume index were correlated with mPAP at baseline; none of the strain parameters were correlated. However, improvements of circumferential and radial strain in inferolateral segment as well as RV end-systolic volume index were independently correlated with reduction of mPAP.

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