FLASH Proton Density Imaging for Improved Surface Coil Intensity Correction in Quantitative and Semi-Quantitative SSFP Myocardial Perfusion Imaging
Sonia Nielles-Vallespin 1 , Peter Kellman 1 , Li-Yueh Hsu 1 , and Andrew E Arai 1
National Institutes of Health, Bethesda, MD,
Perfusion scans preceded by both FLASH and SSFP-PD
frames from 10 patients with no myocardial infarction
were analyzed semi-quantitatively and quantitatively.
Low flip-angle SSFP protocol exhibited severe ghosting
artifacts in 6 of 10 subjects. These artifacts lead to
errors in quantitative perfusion maps and
semi-quantitative perfusion indexes. They can be severe
enough to cause false positives diagnoses. Using
FLASH-PD frames as input for the surface coil intensity
correction (SCIC) improved the homogeneity of perfusion
measurements. Thus, FLASH PD images are recommended for
SCIC of SSFP perfusion images in place of low flip angle
SSFP PD images.
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