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Abstract #4516

The Effects of Injection Rate on Vascular Signal Intensity Profile in a Porcine Model using Four Gadolinium Contrast Agents: Comparison Between Observation and Prediction Based on Measured Blood Relaxivity Values

Jeffrey H Maki 1 , Guenther Schneider 2 , Alexander Massmann 2 , Matthias Leist 2 , Diane Wagner-Jochem 2 , and Gregory J Wilson 1

1 Radiology, University of Washington, Seattle, WA, United States, 2 Radiology, University Hosptial of Saarland, Homburg, Germany

Eight juvenile swine were imaged with high temporal resolution (1.7 s) CE-MRA 3x each during the bolus passage of one of four Gd agents at 1,2,3 ml/sec (2 animals/agent, all single dose, 24 total injections). Simultaneous aortic blood sampling was performed (every 2 s) to measure actual Gd concentration. Ex vivo arterial blood was doped with each contrast agent to determine R1 and R2* vs. [Gd]. Predicted and actual signal intensity (SI) vs. time as well as bolus duration were compared, demonstrating a relatively flat SI response vs. injection rate, validating the benefit of slower Gd injections for CE-MRA.

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