Abstract #0017

Evidence for regional and spectral differences of macromolecule signals in human brain using a crusher coil at 7 Tesla

Nicolas Geades¹, Carrie Wismans², Mariska Damen², Penny Gowland¹, Hans Hoogduin², Vincent Boer², Dennis Klomp², and Jannie Wijnen²

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²Department of Radiology, University Medical Centre Utrecht, Utrecht, Netherlands

The regional, spectral and relaxation differences of macromolecules (MM) in the human brain were investigated using T1 mapping, metabolite nulling and high resolution MRSI with a crusher coil at 7T. Differences between macromolecular signal of GM and WM were observed by all three methods. The T1 mapping showed different T1 relaxation time of MM in GM and WM. Metabolic maps created by fitting an averaged WM spectrum showed differences in M1 and M2. The macromolecules in the metabolite nulled data showed a different M4 in GM and WM. Some of these differences can be explained by differences in T1 relaxation.

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