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Abstract #0016

Characterization of the macromolecular baseline with a metabolite-cycled double-inversion recovery sequence in the human brain at 9.4T

Ioannis Angelos Giapitzakis1,2, Roland Kreis 3, and Anke Henning 1,4

1Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2IMPRS for Cognitive and Systems Neuroscience, University of Tuebingen, Tuebingen, Germany, 3Depts. Radiology and Clinical Research, University of Bern, Bern, Switzerland, 4Institute of Biomedical Engineering, University and ETH, Zürich, Switzerland

Macromolecular resonances (MM) overlap with metabolites resulting in inaccurate quantification of the metabolites due to baseline distortion. This effect becomes even more severe in case of short echo times (TE). The purpose of this study was the development of an adiabatic pulse for double inversion recovery and investigation of impact to include MM into quantification of 9.4T MRS data of human brain. This is the first study where MC-STEAM is combined with a double inversion technique. The results showed the advantages of UHF and MC as well as the necessity of the inclusion of MM baseline in the basis set.

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