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Abstract #0024

Parameterization of measured macromolecular background in ultra-short acquisition delay 1H MRSI in the brain at 7T

Michal Pova┼żan1,2, Gilbert Hangel1, Bernhard Strasser1, Eva Heckova1, Lukas Hingerl1, Stephan Gruber1, Siegfried Trattnig1,2, and Wolfgang Bogner1

1High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

Ultra-short echo/acquisition delay MRS spectra have a strong characteristic background consisting of macromolecule (MM) resonances superimposed on the signal of metabolites. Typically a single metabolite-nulled MM spectrum is included into quantification routine to account for this. To detect more prominent regional and pathologic changes, we replaced this single MM spectrum by individual MM peaks. We found that the MM peaks in a 2.3-0.5 ppm region are higher in gray matter compared to white matter, whereas the MM peaks from 2.9 to 3.2 ppm were significantly higher in white matter of healthy volunteers and one MS patient.

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