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Abstract #0030

Toward Iron Distribution Mapping using Quantitative Susceptibility Mapping (QSM): A Comparison of Histological Iron Concentration Maps with Magnetic Susceptibility Maps

Andreas Deistung1, Verena Endmayr2, Simon Hametner2, Hans Lassmann2, Jürgen Rainer Reichenbach1, Simon Daniel Robinson3, Thomas Haider4, Hannes Traxler5, Evelin Haimburger6, Siegfried Trattnig3, and Günther Grabner3,6

1Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Jena, Germany, 2Center for Brain Research, Medical University of Vienna, Vienna, Austria, 3High Field Magnetic Resonance Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 4University Clinic for Trauma Surgery, Medical University of Vienna, Vienna, Austria, 5Center of Anatomy and Cellbiology, Medical University of Vienna, Vienna, Austria, 6Department of Health Sciences and Social Work, Carinthia University of Applied Sciences, Klagenfurt, Austria

Quantitative susceptibility mapping (QSM) provides a unique view into cerebral iron distribution in vivo. However, not only paramagnetic iron complexes but also diamagnetic myelin around axons contribute to the magnetic susceptibility. To further validate QSM for iron mapping we present a histochemical-driven approach to quantify iron in post mortem brain tissue and compare the spatial distribution of iron with in situ magnetic susceptibility maps. Direct comparison between histological iron concentration and susceptibility maps revealed excellent correspondence between iron accumulations and elevated susceptibility in deep gray matter and can improve the understanding of biophysical origins of susceptibility variations within brain tissue.

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