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Abstract #0031

Feasibility Study of High Resolution Mapping for Myelin Water Fraction and Frequency Shift using Tissue Susceptibility

Zhe Wu1,2, Hongjian He1,2, Ying Chen1,2, Song Chen1,2, Hui Liu3, Yiping P. Du2, and Jianhui Zhong1,2

1Center for Brain Imaging Science and Technology, Zhejiang University, Hangzhou, China, People's Republic of, 2Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, People's Republic of, 3NEA MR Collaboration, Siemens Ltd., China, Shanghai, China, People's Republic of

A three-step method for high resolution myelin water fraction (MWF) and frequency shift mapping of white matter components using tissue susceptibility is presented in this study. Tissue susceptibility induced phase was calculated by the simultaneously acquired QSM from the same multi-echo GRE (mGRE) dataset, and was used as the phase part of complex data for a subsequent fitting to a three-pool white matter model. Benefit from the background phase removal and magnetic dipole deconvolution procedures during QSM calculation, the result reveals much less misfitting when comparing with direct fitting to original mGRE data. These generated quantitative maps can be potentially used for quantitative studies of demyelinated diseases.

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