Abstract #0031

Feasibility Study of High Resolution Mapping for Myelin Water Fraction and Frequency Shift using Tissue Susceptibility

Zhe Wu^1,2, Hongjian He^1,2, Ying Chen^1,2, Song Chen^1,2, Hui Liu³, Yiping P. Du², and Jianhui Zhong^1,2

¹Center for Brain Imaging Science and Technology, Zhejiang University, Hangzhou, China, People's Republic of, ²Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, People's Republic of, ³NEA MR Collaboration, Siemens Ltd., China, Shanghai, China, People's Republic of

A three-step method for high resolution myelin water fraction (MWF) and frequency shift mapping of white matter components using tissue susceptibility is presented in this study. Tissue susceptibility induced phase was calculated by the simultaneously acquired QSM from the same multi-echo GRE (mGRE) dataset, and was used as the phase part of complex data for a subsequent fitting to a three-pool white matter model. Benefit from the background phase removal and magnetic dipole deconvolution procedures during QSM calculation, the result reveals much less misfitting when comparing with direct fitting to original mGRE data. These generated quantitative maps can be potentially used for quantitative studies of demyelinated diseases.

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