Abstract #0033

MRI in Multiple Sclerosis: The curiosity of apparent susceptibility increases at simultaneous iron loss

Vanessa Wiggermann^1,2, Simon Hametner³, Enedino Hernandez-Torres^2,4, Verena Endmayr³, Christian Kames⁵, and Alexander Rauscher²

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²Pediatrics, University of British Columbia, Vancouver, BC, Canada, ³Neuroimmunology, Medical University of Vienna, Vienna, Austria, ⁴UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ⁵Engineering Physics, University of British Columbia, Vancouver, BC, Canada

Quantitative Susceptibility Mapping has shown great potential to be used for clinical diagnoses due to its high sensitivity to change and high spatial resolution. Notably, the ability to quantify damage has been appealing. However, attributing susceptibility increases or decreases to certain mechanisms has been challenging. In particular, interpretation of MR signal changes during multiple sclerosis lesion formation is lacking consistency and histological validation. Here, we investigated the hypothesis that apparent changes of the lesion tissue may be in fact due to changes in the lesions vicinity and caution is required when interpreting the quantitative susceptibility signal in multiple sclerosis lesions.

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