Abstract #0034

Quantitative susceptibility mapping of the rat brain after traumatic brain injury

Karthik Chary¹, Mikko J. Nissi^2,3, Ramón I. Rey⁴, Eppu Manninen¹, Karin Shmueli⁵, Alejandra Sierra¹, and Olli Gröhn¹

¹Department of Neurobiology, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ²Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, ³Finland Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland, ⁴Department of Neurology, Clinical Neurosciences Research Laboratory, Hospital Clínico Universitario, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain, ⁵Department of Medical Physics & Biomedical Engineering, University College London, London, United Kingdom

Our aim was to test the sensitivity of QSM to demyelination, iron and calcifications in a rat model of TBI. Ex vivo QSM data were obtained from five injured and four sham control rats, six months after TBI. Our results showed susceptibility changes in white matter areas consistent with myelin staining. Perilesional cortex became more diamagnetic after TBI. Thalamic nuclei showed variable responses as diamagnetic calcification and paramagnetic iron accumulation occurred in the same brain areas. Overall, QSM showed sensitivity to TBI changes. However, further studies are required to better understand the influence of potentially counteracting pathological processes.

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