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Abstract #0034

Quantitative susceptibility mapping of the rat brain after traumatic brain injury

Karthik Chary1, Mikko J. Nissi2,3, Ramón I. Rey4, Eppu Manninen1, Karin Shmueli5, Alejandra Sierra1, and Olli Gröhn1

1Department of Neurobiology, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 2Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 3Finland Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland, 4Department of Neurology, Clinical Neurosciences Research Laboratory, Hospital Clínico Universitario, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain, 5Department of Medical Physics & Biomedical Engineering, University College London, London, United Kingdom

Our aim was to test the sensitivity of QSM to demyelination, iron and calcifications in a rat model of TBI. Ex vivo QSM data were obtained from five injured and four sham control rats, six months after TBI. Our results showed susceptibility changes in white matter areas consistent with myelin staining. Perilesional cortex became more diamagnetic after TBI. Thalamic nuclei showed variable responses as diamagnetic calcification and paramagnetic iron accumulation occurred in the same brain areas. Overall, QSM showed sensitivity to TBI changes. However, further studies are required to better understand the influence of potentially counteracting pathological processes.

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