Abstract #0035

Suitable reference tissues for quantitative susceptibility mapping of the brain

Sina Straub¹, Till Schneider^2,3, Martin T. Freitag³, Christian H. Ziener³, Heinz-Peter Schlemmer³, Mark E. Ladd¹, and Frederik B. Laun¹

¹Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany, ³Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Since QSM is only able to quantify magnetic susceptibility relative to a reference value, a suitable reference tissue must be available to be able to compare different subjects and stages of disease. To find such a suitable reference tissue for QSM of the brain, melanoma patients with and without brain lesions were measured. 12 reference tissues were chosen and assessed in multiple measurements of the same patient and amongst different patients. The posterior limb of the internal capsule and a cerebrospinal fluid volume in the atrium of the lateral ventricles appeared to be most suitable reference tissues.

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